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SOLIAN (AMISULPRIDE): OVERDOSAGE

Symptoms

Experience with Solian (Amisulpride) in overdosage is limited. Exaggeration of the known pharmacological and adverse effects of amisulpride have been reported. These may include sedation, drowsiness, hypotension, extrapyramidal symptoms and coma.

Fatal outcomes have been reported mainly in combination with other psychotropic agents.

Treatment

In cases of acute overdose by Amisulpride (Solian) tablets and oral solution, the possibility of multiple drug intake should be considered.

There is no specific antidote to amisulpride. Appropriate supportive measure should therefore be instituted: close supervision of vital functions and, because of the risk of prolongation of QT interval, continuous cardiac monitoring until the patient recovers.

If severe extrapyramidal symptoms occur, anticholinergic agents should be administered.

Since Amisulpride (Solian) oral solution and tablets are weakly dialysed, haemodialysis is not recommended as a method of elimination.

For information on the management of overdose, contact any local or central poison information centre.

Poison schedule of Amisulpride (Solian)

Prescription only medicine (Schedule 4) in Australia and New Zeland.



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Mellaril overdosage - Thioridazine Hydrochloride
  • Tablets; Oral; Thioridazine Hydrochloride 15 mg
  • Novartis
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  • Acino Pharma
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