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SOLIAN (AMISULPRIDE): DOSAGE AND ADMINISTRATION
For acute psychotic episodes, oral doses of Amisulpride (Solian) oral solution and tablets between 400 mg / day and 800 mg / day are recommended. In individual cases, the daily dose may be increased up to 1200 mg/d. Doses above 1200 mg / day have not been extensively evaluated for safety and therefore should not be used. Doses above 800 mg / day have not been shown to be superior to lower doses and may increase the incidence of adverse events. No specific titration is required when initiating the treatment with amisulpride. Doses should be adjusted according to individual response.
Doses should preferably be administered before meals.
Amisulpride (Solian) should be administered bid for doses above 400 mg.
For patients with mixed positive and negative symptoms, doses should be adjusted to obtain optimal control of positive symptoms.
Maintenance treatment should be established individually with the minimally effective dose.
For patients characterised by predominant negative symptoms, oral doses between 50 mg / day and 300 mg / day are recommended. Doses should be adjusted individually.
A graduated dosage syringe (pipette) is supplied for dispensing Solian solution. Each one ml graduation is equivalent to 100 mg amisulpride.
Solian (Amisulpride) tablets and oral solution should be used with particular caution because of a possible risk of hypotension or sedation.
Amisulpride is contra-indicated in children up to puberty as its safety has not yet been established.
Amisulpride is eliminated by the renal route. In renal insufficiency, the dose should be reduced to half in patients with creatinine clearance (CRCL) between 30-60 mL/min and to a third in patients with CRCL between 10-30 mL/min. As there is no experience in patients with severe renal impairment (CRCL < 10 mL/min) particular care is recommended in these patients.
Since Solian (Amisulpride) oral solution and tablets are weakly metabolised, a dosage reduction should not be necessary.
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